HORDB

ID: hor001953
Uniprot ID: O42144
Protein name: Glucagon-like peptide 1A
Gene name: gcg2
Organism: Xenopus laevis (African clawed frog)
Family: Glucagon family
Source: Animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Xenopus (subgenus), Xenopus (genus), Xenopodinae (subfamily), Pipidae (family), Pipoidea (superfamily), Anura (order), Batrachia (superorder), Amphibia (class), Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007165 signal transduction; GO:0050896 response to stimulus
GO CC: GO:0005576 extracellular region

Sequence: HAEGTFTSDVTQHLDEKAAKEFIDWLINGGPTKEIIS
Length: 37(97-133)
Propeptide: MKSTCYMIGILLLILQNTYQSPVPEADGSSRSVKAARNEAVDDSEQLKEVKRHSQGTFTSDYSKYLDSRRAQDFVQWLMNTKRSGGLSRRNADYERHAEGTFTSDVTQHLDEKAAKEFIDWLINGGPTKEIISRRNAEIERHAEGTYTNDVTEYLEEKATKAFIEWLIKGKPKKIRYSRHAEGTFTNDMTNYLEEKAAKEFVGWLINGRPKRKDLLEEH
Signal peptide: MKSTCYMIGILLLILQNTYQ
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: Promotes hydrolysis of glycogen and lipids, and raises the blood sugar level.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
Kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor001953_AF2.pdb

hor001953_ESM.pdb

Mass:	474185	Formula:	C183H281N47O60
Absent amino acids:	CMRY	Common amino acids:	EIT
pI:	4.45	Basic residues:	5
Polar residues:	10	Hydrophobic residues:	13
Hydrophobicity:	-45.68	Boman Index:	-5853
Half-Life / Aliphatic Index:	3.5 hour	Aliphatic Index:	79.19
Instability Index:	1425.14	Extinction Coefficient cystines:	5500
Absorbance 280nm:	152.78